Relationship between renin gene G10631A, T704C polymorphism of angiotensinogen gene and cerebral infarction

Objective To investigate the relationship between renin （REN） genne G10631A, angiotensinon （AGT） gene T704C mononucleotide polymorphisms and cerebral infarction and to investigate the mechanisms and characteristics of cerebral infarction from molecular level. Methods REN gene G1063A and AGT gene T704C polymorphisms in 82 patients with cerebral infarction and 89 controls were detected with polymerase chain reaction- restriction fragnent length polymorphism. The differences of the genotypes and allele frequencies were compared between the patient group and the control group. Results The frequency of REN 10631AA genotype （31.7% vs. 10. 1% ,χ2 =12. 816, P =0. 002） and the frequency of A genotype （49. 4% vs. 30. 3%χ2 = 12. 969, P =0. 000）, as well as the frequency of AGT 704 CC genaotype （63.4% vs. 34. 8% χ2 = 15. 029, P = 0. 001） and the frequency of A genotype （79. 9% vs. 61.2% χ2 = 14. 173, P =0. 000） in the cerebral infarction group were all signifi- cantly higher than those in the control group; the frequency of haplotype 704C 10631A was also significantly hiher than that in the control group （P =0. 000）. Conclusions REN 10631AA genetype and A allele as well as AGT 704 CC genaetype and C allele may be the susceptible factors of cerebral infarction. Haplotype 704C-10631 A may be a genetic risk factor for the occurrence of cerebral infarction. Key words: Brain infarction;  Stroke;  Renin;  Angiotensinogen;  Polymorphism, Genetic;  Haplotypes