The relationship between thromboxane A_2 receptor gene polymorphism and cerebral infarction

Objective To investigate the relationship between thromboxane A_2 receptor (TXA_2R) gene polymorphism and cerebral infarction in Shanghai Han ethnic population.Methods A genetic association study of one single nucleotide polymorphism(SNP,rs768963) in the human TXA_2R gene was performed in 138 patients with cerebral infarction and 135 normal elder controls by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and calculated the distribution of genotype and allelic gene frequency.Results Logistic regression analysis indicated that blood pressure and serum glucose were independent risk factors for cerebral infarction,and there were no significant differences in the frequency of genotype(TT,TC and CC genetype)and allelic gene (T and C) of rs768963 between cerebral infarction group and control group(P0.05, for all).Further analysis showed that there were no association between the mutant of rs768963 and factors including gender,age,blood lipid,blood pressure and serum glucose.Conclusion There may be no association between the SNP (rs768963) polymorphism in the human TXA_2R gene and cerebral infarction in Shanghai Han ethnic population.