2003•Journal of LeukemiaRequires access

CLINICAL STUDY OF REVERSAL EFFECT OF MULTIDRUG RESISTANCE IN ACUTE LEUKEMIA CELLS BY INTERLEUKIN-2

Qing Jia

Abstract

Objective:To investigate reversal effect of multidurg resistance in acute leukemia cells by interleukin 2(IL 2).Methods:27 patients with refractory and relapsed acute leukemia were elected.P glucoprotein (p170),lung resistance related protein (LRP) and clinical remission ratio was analysed after treatment of the patients.Results:The patients with acute leukemia treated by IL 2 and chmotherapy had lower expression of P 170 and LRP and high remission ratio than patients treated with only chmotherapy.There was statistical significant comparison ( P 0.05).Conclusion:Interleukin 2 has reversal effect of multidrug resistance in acute leukemia cells.It acted by lower express of P 170 and LRP.

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Key concepts: Acute leukemia, Leukemia, Refractory (planetary science), Medicine, Multiple drug resistance, Interleukin, Internal medicine, Immunology