The changes of the serum IL-6 and C-reactive protein and their clinical significance in patients with progressive ischemic stroke

Objective To explore the role of the serum IL-6 and C-reactive protein(CRP)in pathogenesis of progressive ischemic stroke.Methods The levels of serum IL-6 and CRP in different stages in 80 patients with acute cerebral infarction were determined by double-antibody sandwich enzyme-linked immunosorbent assay and transmission turbidimetry,and the development of progressive stroke was determined on the basis of the clinical neurological deficits scale(NDS)score.The other 40 healthy volunteers were used as control group.Results Of 80 patients with acute cerebral infarction progressive stroke were found in 27 patients(33.75%)within 7 days of stroke.The levels of IL-6 and CRP in peripheral blood at 1st d,3rd d,7th d,14th d after stroke in patients with progressive stroke were significantly higher than that in patients without progressive stroke(P all0.05).There was no significant difference in levels of IL-6 and CRP at 14th d between progressive stroke group and normal control group(P0.05).IL-6.CRP were risk factors of progressive stroke.The levels of IL-6 and CRP on the first day were positively correlated with the body temperature,blood white cell count,plasma fibrinogen on admission(correlation coefficient r=0.87,0.66, 0.51,P all 0.01).Conclusion The increase of serum IL-6 and CRP were closely related to progressive ischemic stroke,and may play an important role in the pathogenesis of ischemic stroke.Monitoring the levels of serum IL-6 and CRP has a great significance for monitoring conditions of disease activity and severity.