A controlled trial of singly used olanzapine and olanzapine combines with lithium in treating patients with bipolar disorder acute mania

Objective:To evaluate the efficacy and safety of olanzapine and olanzapine combined with lithium in the treatment of bipolar or mixed type mania. Method:60 patients were randomly received olanzapine(n=29) or olanzapine combined with lithium(n=31) for 4week.Patients were assessed every week by Young mania scale(YMRS) ,Montgomery-Asberg depression rating scale,and clinical global impression scale-bipolar disorde version to evaluate efficacy.At 1、2、3、4 weekends,the scales of tolerance were used to evaluate safety. Results:At the endpoint,compared to baseline,the improvement for YMRS were significant in both groups.The monotherapy group decreased from(30.10±5.86) to(11.21±6.54)(P0.01) .The concomitant therapy group decreased from(29.48±5.89) to(3.39±5.52)(P0.01) .The concomitant therapy group was more significant in these two group on the improvement for YMRS(P0.05 or P0.01) .The remission rate of the monotherapy group was 57.1%.The remission rate of the concomitant therapy group was 90.3%.The rating scales of tolerance were similar in both groups. Conclusion:Either used olanzapine singly or combined with lithium all had exact therapeutic effect in trial mania episode.Combined olanzapine and lithium was better in improving the mania symptoms,there was no obviously difference beween these two treatments .