Correlation of the Adiponectin Level and Gene Polymorphism with the Essential Hypertension

Objective To explore the relationship of the adiponectin(APN) level,single nucleotide polymorphism(SNP) +45 T / G and +276 G/T with the essential hypertension(EH).Methods 238 subjects were divided into control group and EH group.Experimental-control study was used.Concentration of the plasma adiponection and polymorphisms of the two polymorphisms of adiponectin were detected with enzyme-linked immunosorbent assay(ELISA) and polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP).Results Comparing with the control group,APN of the EH group significantly reduced and the genotype frequency of EH group on SNP+276T alleles rised significantly,Multiple linear regression(MLR) analysis showed that SNPS +276 locus was risk factor of EH.Conclusion APN level of patients with EH decline;People who carries the SNP + 276T alleles run more risk at EH.