Relationship of the adiponectin level and gene polymorphism with the metabolic syndrome

Objective:Researching the relationship of the adiponectin(APN) level,single nucleotide polymorphism(SNP) +45 T/G and +276 G/T with the metabolic syndrome(MS).Method:The total of 238 patients were divided into normal control group and MS group.Adopting experimental-control study,applying the technique of enzyme-linked immunosorbent assay(ELISA) and polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP) to detect concentration of the plasma adiponection and polymorphisms of the two polymorphisms of adiponectin.Result:Comparing the two groups,APN of the MS group reduced(P0.05),the genotype frequency of MS group on SNP+276T alleles goes up obviously.Proceeding multiple factors gradually logistic,regression analysis shows that SNP+276 locus are risk factors to effect MS.Conclusion:APN level of patients with MS decline;People who carries the SNP+276T alleles would run more risk on affecting MS.