Drug resistance of Escherichia coli strains isolated from children with urinary tract infection

Objective To study Escherichia coli infection in children and its resistance.Methods Medistream urine was cultured.Susceptibility test was operated by Kirby-Bauer Method.Extended Spectrum β-lactamases(ESBLs) were detected by Phenotypic confirmatory test.Drug resistance was analysed with WHONET 5.5 software(x2 test).Results From January 2009 to December 2011,85 Escherichia coli strains were detected in the medstream urine samples from the pediatric clinic and ward,and the detective rate was 4.8%.The ratio of men to women was 6:11;3-year-age group(n=57) accounted for 67.1%;3 to 6-year-age group(n=17) 20.0%;6-year-age group(n=11) 12.9%;ESBLs-producing Escherichia coli 60.0%.85 Escherichia coli strains were sensitive to imipenem and meropenem;the resisitance rates to cefoperazone/sulbactam,piperacillin/tazobactam and amikacin were higher than 90%,and the resistance rates of ESBLs-producing Escherichia coli to ampicillin,cefazolin,ceftazidime,ceftriaxone,cefepime,cefoxitin,cefuroxime,levofloxacin and roxithromycin were significantly higher than non-ESBLs-producing Escherichia coli(P0.05).Conclusion Antibiotics that can be selected and used to treat children's urinary tract infection by Escherichia coli are extremely limited.Careful clinical medication and prompt adjustment of drugs should be based on susceptibility results.