The influence of endoscopic injection of lauromacrogol on portal hypertension gastropathy in patients with esophageal varices

[Objective]To investigate the influence of endoscopic sclerotherapy with lauromacrogol on portal hypertension gastropathy(PHG)in patients with esophageal varices. [Methods]One hundred patients with esophageal varices caused by portal hypertension who underwent endoscopic sclerotherapy with lauromacrogol were collected.The statuses of PHG before and after the sclerotherapy were analyzed. [Results]There were 33 patients(33%)who had PHG before taking sclerotherapy.After the first injection,the number of patients with PHG increased to 74(74%),then raised to 88(88%) after two or more injections.The incidence of PHG was significantly increased after endoscopic sclerotherapy(P0.01),which was related to the frequency of therapy taken(P0.01). [Conclusion]Endoscopic injection sclerotherapy was likely to induce and aggravate the PHG while controlling variceal hemorrhage and obliterating varices,but most cases were mild.The patients should go for surgery when variceal hemorrhage is under control,or take long-term medication to lower the pressure of portal system,in order to improve the PHG and prevent bleeding.