2005•Zhongguo yaolixue tongbaoRequires access
The study on inhibitory effects and mechanism of Maoeryan vegetable acid on human SGC-7901 strain cells
Mingren Xie
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Abstract
Aim To study the inhibitory effect of Maoeryan vegetable acid on human SGC-7901 strain cells and the mechamism of it. Methods The inhibitory effects of Maoeryan vegetable acid on human SGC-7901 strain cells were determined by flow cytometry, methods of MTT and trypan-blue.Results Maoeryan vegetable acid at a does of 10.0, 1.0 and 0.1 mg·L -1 was given to human SGC-7901 strain cells for 48 h,respectively, and the inhibitory rate of human SGC-7901 strain cells was 82.9%,42.7% and 24.6%,respectively;cellular growth inhibitory rate was 76.4%,56.9% and 42.6%, respectively;as well as apoptosis rate was 26.8%,22.5% and 15.6%, respectively. Conclusion The Maoeryan vegetable acid has significant inhibitory effect on human SGC-7901 strain cells and the inhibitory effect increases with the increase of concentration and time.