Clinical efficacy analysis of amoxicillin clavulanate potassium combination drug therapy on peptic ulcer and the eradication of HP

Objective To investigate and analyze the efficacy of amoxicillin clavulanate potassium combination drug therapy on peptic ulcer and the eradication of H.pylori.Methods 121 patients with peptic ulcer were randomly divided into the treatment group(61 cases) and the control group (60 cases),patients in the control group were treated with esomeprazole,clarithromycin and amoxicillin,while patients in the treatment group were treated with amoxicillin clavulanate potassium tablet instead of amoxicillin on basis of the control group.Results The efficiency of the control group and the treatment group were 88.3% and 98.4% respectively,the HP eradication rates were 78.3% and 91.8%,and the recurrence rate within 6 months,were 1.6% and 13.3% individually,there were statistically significant between the two group (P0.05,P0.05,P0.01).The incidences of adverse reaction of the control group and the treatment group were 18.0% and 15.0%,with no statistically significant (P0.05).Conclusion Compared with the combination regimen of amoxicillin,amoxicillin clavulanate potassium combination drug therapy is more effective in improving the healing rate,HP eradication rate and reducing the relapse rate,with lower incidence of adverse reactions,which is a perfect regimen in treatment of HP related peptic ulcer.