Efficacy and safety of insulin glargine in combination with sitagliptin on elderly patients with type 2 diabetes

Objective To investigate the efficacy and safety of insulin glargine in combination with sitagliptin on elderly patients with type 2 diabetes.Methods 78 patients(60 year-old) were randomly divided into two groups:insulin glargine/sitagliptin combination group(n=40,group G)and biosynthesis premixed 30/70 insulin group(n=38,group N).The dose was adjusted according to blood glucose,the fasting glucose,2 h postprandial blood glucose,glycosylated hemoglobin(HbA1c),the incidence of hypoglycemia and body mass index(BMI)after 12 weeks of treatment of the two groups were compared.Results 2 h postprandial blood glucose and the incidence of hypoglycemia in group G were less than those in group N(P0.05).The was no significant difference in postprandial blood glucose,HbA1c and BMI between the two groups(P0.05).Conclusion The treatment of insulin glargine in combination with sitagliptin is safe,effective and convenient for elderly patients with type 2 diabetes.This treatment program with a small incidence of hypoglycemia is very suitable for old patients with type 2 diabetes complicated with poor cognitive activities inconvenient,poor eyesight or a variety of chronic diseases.