Observation of the efficacy and safety of sitagliptin insulin glargine in the treatment of type 2 diabetes mellitus

Objective To evaluate the efficacy and safety of sitagliptin insulin glargine in the treatment of type 2 diabetes mellitus.Methods 46 patients with 2 or more oral hypoglycemic agent treatmented and unexpected efficacy,were randomly assigned to 2 groups: each group were 23 patients,Group A received sitagliptin insulin glargine,Group B received premix insulin.FPG 3.9-7.2mmol/L was the therapeutic goal after 12 weeks treatment.FPG,2hPG,Hba1c and BMI before and after 12 weeks were compred.Results After 12 weeks treatment,the levels of FPG,2HPG,HbA1c decreased significantly compared to baseline in both groups(P0.001),and there was no significant difference between the 2 groups(P0.05),BMI of sitagliptin group was no significant difference,BMI of premix insulin group was increased(P0.05).Conclusions The method can reduce glycaemia frequency.and the treatment is safe and has good compliance.