Effect observation of Sitagliptin combined insulin glargine in treatment of type 2 diabetes

Objective To observe the efficacy and safety of combined insulin glargine treatment of type 2 diabetes,sitagliptin.Methods Totally 90 patients with type 2 diabetes were randomly divided into two groups and the control group 45 cases in each group.Observation group received insulin glargine combined sitagliptin treatment,control group received insulin glargine therapy,treatment for 6 weeks after the two groups were compared before and after treatment in patients with glycosylated hemoglobin(HbA1e),2h postprandial blood glucose(2hPG),fasting blood glucose(FBG) levels and clinical efficacy.Results Two groups after treatment,total effective rate was 86.7% higher than the 71.1%(P0.05);And after treatment,HbA1c,2hPG,FBG levels were decreased(P0.05),and the observation group decreased more significant,the difference was statistically significant(P 0.05).Conclusions Insulin glargine in patients with good compliance and co-sitagliptin,a low incidence of hypoglycemic events,can effectively control blood sugar,is an ideal combination therapy.