Association of NRF-1 +141G/T Polymorphism with Coronary Artery Disease in Han Population of Northern China

Objective: The aim of the present study was to investigate the association between IRF-1 +141 G/T polymorphism and coronary artery disease in Han population of Northern China. Methods: A case-control study was conducted in 675 patients with coronary artery disease and 636 controls who had normal coronary angiograms. Polymorphic genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. Results: The genotype frequencies in IRF-1 +141 G/T polymorphism conformed well to the Hardy-Weinberg equilibrium in both controls and case, and were 53.8 %(GG), 36.2 %(GT), 10.1 %(TT) in case group and 45.6 %(GG),46.2 %(GT), 8.2 %(TT) in the controls. There were significant differences in the genotype and allele distribution of +141 G/T polymorphism of the IRF-1 gene between cases and controls(P0.05). Logistic regression analysis with adjustments for other risk factors revealed that the IRF-1 +141 G/T allele carriers significantly increases the risk of coronary artery disease compared with the non-carriers(P0.05). Conclusions: This study shows that the IRF-1 +141 G/T polymorphism may be considered a genetic risk factor for coronary artery disease in Han population of Northern China.