Association of IL-17A-121G/A polymorphism and premature coronary artery disease in Han population of North China

Objective To assess the possible association between interleukin17A(IL-17A) and premature coronary artery disease(CAD).Methods A total of 520 patients with CAD and 480 healthy adults were genotyped by polymerase chain reaction and DNA sequence technology for the-121A/G polymorphism of IL-17A gene.Results There was IL-17A gene-121A/G polymorphism in Northern Chinese Han population.The genotype frequencies of GG,AG and AA in the IL-17A-121G/A polymorphism were 86.9%,12.2% and 0.9% in CAD,81.2%,17.8% and 1.0% in the controls respectively.The frequencies of GG genotype and G allele were significantly higher in patients with CAD than those of controls(OR=0.68,95% CI=0.49~0.94,P=0.02).Subsequent stratified analysis by gender also showed there was a statistical significance in the genotype and allele frequencies between the male patients and control group(OR=1.56,95% CI=1.04~2.28,P=0.02).A binary logistical regression analysis suggested the IL-17A-121G/A polymorphism correlated with CAD(P0.05).Conclusions IL-17A gene-121G/A polymorphism associates with the risk of CAD,and G allele carriers may be a possible genetic susceptibility factor for patients with CAD in Northern Chinese Han population.