Relation of PGC-1α rs3774923 polymorphism and coronary artery disease in a Chinese Han population

Objectives To investigate the relation between peroxisome proliferator-activated receptor γ coactivator-1(PGC-1α) rs3774923 polymorphism and coronary artery disease in Chinese Han population. Methods A case-control study was conducted in 675 patients with coronary artery disease(case group) and 636 control subjects who had normal coronary angiograms(control group). Polymorphic genotypes were determined by polymerase chain reaction-restriction fragment length polymorphisms. Results The genotype frequencies in PGC-1α rs3774923 polymorphism well conformed to th e Hardy-Weinberg equilibrium in both control and case groups. There were no significant differences in the three genotypes [GG: 60.0% vs. 58.2%; GA: 30.2% vs. 35.2%; AA: 9.8% vs. 6.4%; P0.05] and allele distribution [G allele: 75.1% vs. 75.9%;A allele: 24.9% vs. 24.1%; P0.05] of PGC-1α polymorphism between case group and control group. Logistic regression analysis with adjustments for other risk factors revealed that PGC-1α rs3774923 polymorphism was not a risk factor of coronary artery disease(P0.01). Conclusions This study shows that PGC-1α rs3774923 polymorphism should not be considered as a genetic risk factor for coronary artery disease in Chinese Han population.