Correlation between plasma homocysteine level and cerebral infarction and primary hypertension

Objective To investigate the correlation between plasma homocysteine(Hcy) level and cerebral infarction and primary hypertension.Methods Sixty patients with cerebral infarction and hypertension were enrolled as group A,thirty patients with primary hypertension were selected as group B,and 30 healthy individuals were selected as the control group.The plasma levels of Hcy was detected in the three groups,and the traditional risk factors of cerebral infarction were recorded.Severity of cerebral infarction was assessed by NIH Stroke Scale(NIHSS).Results Plasma levels of Hcy in group A,group B and the control group were(27.16±10.46) μmol/L,(20.11±3.17) μmol/L,and(13.35±1.82) μmol/L,respectively,with statistically significant difference between the three groups.Plasma levels of Hcy was found to have no significant correlation with the levels of blood glucose,triglyceride,LDL,blood pressure in group A.Patients in group A was divided into hyper homocysteine(Hcy) group and non HHcy group.NIHSS of Hcy group(6.97±3.76) was significantly higher than that of non Hcy group(2.82±1.01).However no statistically significant difference in blood pressure was found between the two groups.Conclusion Hyper homocysteine was an independent risk factor for cerebral infarction.Patients with cerebral infarction should be detected for plasma Hcy levels.