Analysis on the correlation of homocysteine levels and the traditional risk factors in patients with cerebral infarction

Objective To study the changes of homocysteine(Hcy) levels in patients with cerebral infarction in order to investigate whether the increase of Hcy is an independent risk factor for cerebrovascular disease,and to observe Hcy and other traditional risk factors for guiding clinical treatment and prevention.Methods Hcy was determined by cyclic enzymatic method.A total of 292 patients with cerebral infarction were enrolled,and 80 healthy subjects were as control group.The blood pressure,fasting glucose(Glu),triglyceride(TG),total cholesterol(TC),lipoprotein(a) and uric acid(UA) were determined.The correlation of traditional indicators and Hcy was analyzed by correlation coefficient(r) with regression analysis.The results of patients with cerebral infarction and control group were analyzed.Results Hcy level was(18.19 ± 7.26)μmol / L in patients with cerebral infarction.The Hcy level in control group was(11.23 ± 5.46) μmol / L(P0.05).If the Hcy level 20 μmol/L was settled as high Hcy hematic disease diagnosis standard,the incidence rate in patients with cerebral infarction was 20.5%,and the incidence rate in control group was only 1.2% with statistical difference(P0.05).In cerebral infarction patients,the Hcy level of males was(19.84±7.87) μmol / L,which was significantly higher than that of females [(12.38 ± 7.42)μmol / L](P0.05).Age,smoking history,fasting Glu,TG and TC had no statistical significance(P0.05).In a variety of traditional risk factors for cerebral infarction,the correlation of UA and Lp(a) with Hcy was positive,and r were 0.040 and 0.044(P0.05).Age,diastolic blood pressure,Glu,TG and TC had no correlation with Hcy levels(P0.05).Conclusions High Hcy hyperlipidemia is an independent risk factor for cerebral infarction,UA,Lp(a) and Hcy are closely related.