The recurrent abortion karyotype analysis among chromosomal abormality

Objective:To study the correlation of chromosome karyotypes and recurrent abortion.Methods:Collecting information about those courples who have detected the hromosome karyotypes of circular lymphocytes in the centre of our hospital from July 2010 to November 2012.Results:Out of 206 cases,46 cases of abnormal chromosome were found(female 13 male 33),accounting for 22.33% of total cases.Including 22 cases of autosome Abnormalities:6 cases of balanced reciprocal translocation and 2 cases of inversions,4 cases of satellite increases,9 cases of secondary constriction increases and 1 case secondary constriction decrease.24 cases of sex chromosome abnormalities:20 cases of large Y chromosome(at the same time 2 cases of secondary constriction increases,1 case of satellite increases) and 1 cases of inversions of Y chromosome.3 cases chromosome numerical abnormality,both of them are chimaeras.Conclusion:There is a close relationship between chromosome karyotypes and recurrent abortion,practical genetic consultation,antepartum screening and preimplantation genetic diagnosis are necessary to the couples for the purpose of depressed.