Analysis of Chromosome Structural Abnormalities in Recurrent Abortion

ve: To investigate the relationship between recurrent abortion and chromosome structural abnormalities. Methods: Analysis for chromosome karyotype was performed on peripheral blood from 112 couples with the history of recurrent abortion. Results: Abnormal chromosome karyotypes were found in 20 cases of all the 112 couples accounting for 8. 9% of the total. Among the abnormalities, four cases were balanced translocation, one case was complex translocation, eight cases were inversion between arms, six cases Y chromosome mutation, and one case of somatic chromosome mutation, accounting for 1. 8%, 0.4%, 3. 6%, 2. 7% and 0. 4% respectively. Conclusion: Disfavorable pregnancy such as abortion may result from chromosome structural aberration or variation in any side of the couple with recurrent abor-tion. The 9th chromosome inversion and Y chromosome variety are closely related to the early abortion.