Effect of Probucolin in the treatment of hyperlipemia nonproliferating diabetic retinopathy

Objective To explore the clinical curative effect of probucolin in the treatment of hyperlipemia nonproliferating diabetic retinopathy(DR).Methods 100 eyes of 50 patients clinical diagnosed hyperlipemia nonproliferating diabetic retinopathy(DR) in our hospital from September 2011 to September 2012 were treated.The patients were randomly and equally divided into two groups,namely the treatment group and the control group,each group had 50 eyes of 25 patients.The patients of two groups were given the same diet and exercise guidance,and taken hypoglycemic drugs or injected insulin to control the blood sugar and blood pressure.On the basis,the patients in the treatment group were treated with probucol,while the patients in the control group only received atorvastatin.The patients were given long-term treatment,and the various indicators were observed and analyzed.Results Compared with before treatment,the microaneurysm of patients in the treatment group and the control group reduced,and the total effective rate was 68.26%,34.45% respectively,the difference was statistically significant(P0.05).The total effective rate of vision upswing after treatment in the treatment group and the control group was 45.28%,42.36% respectively,and the difference was not statistically significant(P0.05).Compared with before treatment,the number of macular edema after treatment in two groups reduced obviously,and the difference was statistically significant(P0.05).The triglyceride,low density lipoprotein cholesterol and total cholesterol of patients after treatment decreased significantly,and the 8-hydroxydeoxyguanosine of the treatment group was lower than that of the control group.Conclusion Probucolin for hyperlipemia nonproliferating diabetic retinopathy(DR) can reduce blood lipid,recover vision,effectively reduce macular edema,and is worthy of clinical promotion and application.