Effect of Hepatic-protective in Jiejiuxiaozhi Decoction on Rats of Alcoholic Fatty Liver

Objective: To investigate the prevention and treatment effects of Jiejiuxiaozhi Decoction on rats with alcoholic fatty liver(AFL).Methods: Male SD rats were randomly divided into the normal group,the model group,the Compound Yiganling Tablet group,the Jiejiuxiaozhi Decoction low dose group,the Jiejiuxiaozhi Decoction middle dose group and the Jiejiuxiaozhi Decoction high dose group.The normal group and the model group were administered saline.The other groups were given corresponding medicine by gavage for 6 weeks.After having given medicine for 6 weeks,the following indexes were observed and detected such as the weight,the liver index,the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),glutamyltranspeptidase(GGT),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C) in serum.Results: Compared with the model group,,fatty degeneration and inflammation were significantly reduced in the Jiejiuxiaozhi Decoction middle dose group and high dose group.The following indices were significantly decreased such as liver index,the contents of AST,ALT,GGT,TG,TC,LDLC in serum.However,the following indicators were significantly increased including body weights,the contents of HDL-C in serum.All the experimental data had statistical significances.Conclusion: Jiejiuxiaozhi Decoction can significantly reduce fatty degeneration and inflammation,improve liver function and decrease blood lipid capacity.