A clinical study on Jingganquzhi decoction(净肝祛脂汤) in treating non-alcoholic fatty liver

Objective To observe the therapeutic effect of Jingganquzhi decoction(JQ,净肝祛脂汤) in treating non-alcoholic fatty liver.Methods Eighty patients with non-alcoholic fatty liver were randomly divided into treatment group to receive JQ and control group to receive Dongbaogantai(DG,东宝肝泰) orally for 3 months.The changes of liver function,blood lipids,B ultrasonic examination were observed.Results After the treatment,the liver function criteria: alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),γ-glutamyltransferase(γ-GGT) and blood lipids of triglycerides(TG),total cholesterol(TC) were lower than those before the treatment,while the high-density lipoprotein cholesterol(HDL-C) was higher than that before the treatment in both groups(all P0.01).The liver function criteria of ALT,AST,ALP and blood lipids of TC and TG of the treatment group were significantly decreased compared with those of the control group,and HDL-C was increased compared with that of the control group(all P0.05),the improvement of B ultrasonic examination was significantly better in treatment group than that in the control group(40.0% vs.20.0%,P0.05).The healing rate and total therapeutic effective rate in the treatment group was obviously better than that in the control group(healing rate: 25.0% vs.10.0%,total therapeutic effective rate: 85.0% vs.60.0%,both P0.05).Conclusion JQ is obviously effective in treating non-alcoholic fatty liver with favorable safety.