The relationship between the titer of serum antibody of blood-type O gravidas and the occurrences of ABO hemolytic disease among newborn infants

Objective:To study the relations between the blood type antibody titer of 232 blood-type-O gravidas and the occurrences of hemolytic disease and jaundice among newborn infants.Methods:According to the titer of serum IgG antibody A(B) of blood-type O gravidas taken during their 20 to 32 week gravidity, divide the newborn infants into four groups (≤1∶32,1∶64,1∶128,≥1∶256),carry out three kinds of tests with the infants' blood of vein including the serum coombs test, antibody release test and free antibody test so as to verify ABO hemolytic disease, to monitor the development of icterus and carry out early treatment.Results:The occurrence of newborn infant's ABO hemolytic disease is in connection with its mother's antibody titer.The higher the titeris,the higher the occurrence rate of hemolytic diseaseis. The difference is remarkable (P0.05). At the same time the frequency of jaundice is also higher with a remarkable difference(P0.5).Conclusion:With gravida's rise of the titer of serum IgG antibody, newborn infant tends to have a frequent occurrence of ABO hemolytic disease and jaundice. It is necessary to undertake supervision and treatment of infants' jaundice in an early stage