Relationship of the titer of blood group antibody in pregnant women with ABO blood type and hemolytic disease of the newborn due to ABO incompatibiity

Objective To investigate the relationship between O、A and B blood type of newborn and blood group antibody titer in pregnant women,and whether the fetal hemolytic status would be predicted by the blood group antibody titer when antibody titer was more than 1∶512 in blood group incompatibility. Methods We retrospectively analyzed the data of 354 pregnant women with blood group O and their husbands with blood group A,B,or AB.The serologic test of hemolytic disease of newborn was performed immediately after delivery in umbilical and mothers blood sample. Results Anti A or anti B IgG antibodies could be examined despite newborn was O、A or B blood type.Anti A or anti B IgG antibody titer of mothers hadn't significant difference between O and A,B blood group of newborn.The rate of ABO hemolytic disease of newborn was positive correlation with mothers antibody titer.But the rate of hemolytic anemia of newborn did not increase when the antibody titer was more than 1∶512. Conclusions The immune antibody titer of pregnant women can be independent of newborn blood type,and the antibody titer more than 1∶512 can also not be used to predict the severity of ABO hemolytic disease of newborn.