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Research Progress on Anti-fibrosis Therapy Targeted Hepatic Stellate Cell Activation

Wang Pi-lon

Abstract

The hepatic stellate cell (HSC) activate and convert into myofibroblast cell is the core link of the development of liver fibrosis.Transforming growth factor β1(TGF-β1) is a key factor to mediate the start and the activation of the HSC.Interference TGF-β 1 and its cell signal introduction way is a hot point on research of hepatic fibrosis therapy.This article reviewed the development of this aspect.

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Available abstract

Key concepts: Hepatic stellate cell, Myofibroblast, Hepatic fibrosis, Transforming growth factor, Liver fibrosis, Fibrosis, Cell, Cancer research