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Research Progress in Smad and Hepatic Fibrosis

Zhao Yong-zhon

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Abstract

Hepatic stellate cells(HSC)is the key to the development of liver fibrosis cells,and transforming growth factor β1(TGF-β1)is the main factor to promote the activation of HSC and the synthesis of extracellular matrix(ECM).In the process of liver fibrosis,the signal transduction of TGF-β1/Smad plays an important role on the HSC.TGF-β1/Smad-depth study of signal transduction pathway may be further elaborated in the pathogenesis of hepatic fibrosis,and provide a new way to keep out hepatic fibrosis.

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What this paper is about

Hepatic stellate cells(HSC)is the key to the development of liver fibrosis cells,and transforming growth factor β1(TGF-β1)is the main factor to promote the activation of HSC and the synthesis of extracellular matrix(ECM).In the process of liver fibrosis,the signal transduction of TGF-β1/Smad plays an important role on the HSC.TGF-β1/Smad-depth study of signal transduction pathway may be further elaborated in the pathogenesis of hepatic fibrosis,and provide a new way to keep out hepatic fibrosis.

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Available abstract

Hepatic stellate cells(HSC)is the key to the development of liver fibrosis cells,and transforming growth factor β1(TGF-β1)is the main factor to promote the activation of HSC and the synthesis of extracellular matrix(ECM).In the process of liver fibrosis,the signal transduction of TGF-β1/Smad plays an important role on the HSC.TGF-β1/Smad-depth study of signal transduction pathway may be further elaborated in the pathogenesis of hepatic fibrosis,and provide a new way to keep out hepatic fibrosis.

Key concepts: SMAD, Hepatic stellate cell, Hepatic fibrosis, Extracellular matrix, Signal transduction, Transforming growth factor, Fibrosis, Pathogenesis

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