2009•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access
Effects and mechanisms of hepatic stellate cells (HSC) activation and proliferation-related signal transduction pathway in liver fibrosis
Feihu Chen
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Abstract
The activation and proliferation of hepatic stellate cell(HSC)have been considered to play an important role in hepatic fibrosis.The manipulation of the activation and proliferation of hepatic stellate cells and the process of liver fibrosis inversion are the key in anti-liver-fibrosis researches.This paper briefly reviews the hepatic stellate cells(HSC) activation and proliferation-related signal transduction pathway and explores the role in the pathogenesis of liver fibrosis.It is a new way to study the pathogenesis and therapy of liver fibrosis through intervention of HSC activation and proliferation-related signal transduction pathway.