TNF-α and IL-6 in the Incidence of Type 2 Diabetes Macrovascular Complication:A Study of Predictive Value

Objective To explore the predictive value of TNF-α and IL-6 in the incidence of type 2 diabetes(T2DM)macrovascular complication.Methods All participants were divided into T2DM group(215 cases)and control group(112 healthy blood donors).TNF-α and IL-6 were analyzed in electro-chemical luminescence method.Every year,all participants received various examinations,including examination of intima of carotid artery and lower limb arterial ultrasonic,computerized tomographic scanning of cranium and electrocardiography.Results(1)The incidence rate of macrovascular atherosclerosis was significantly higher in T2DM group than that in the control group(P0.01).(2)The levels of TNF-α and IL-6 in those with atherosclerosis increased year by year in both groups;But there was no significant difference in levels of TNF-α and IL-6 between two groups(P0.05).(3)Significant difference was found in levels of TNF-α and IL-6 between patients with atherosclerosis and those without atherosclerosis(P0.05).Conclusion The elevated levels of TNF-α and IL-6 predict the incidence of type 2 diabetes macrovascular complication.But no evidence can be found to prove the existence of specific inflammation mechanism in type 2 diabetes macrovascular complication.Inflammation mechanism is not the reason for earlier occurrence,faster progress and worse prognosis of diabetes macrovascular complication in patients with diabetes than healthy persons.One of the reasons why hyperglycemia causes atherosclrosis is the activation of induction inflammatory cell to make inflammatory factors discharge,but there is not any quantity-effect correlation.