The clinical significance of the detection of serum hs-CRP and interleukin-17 in senium type 2 diabetes with macroangiopathy

Objective To explore the relationship between serum hs-CRP,IL-17 levels and senium type 2 diabetic macrovascular complications and its clinical significance. Methods The serum levels of hs-CRP and IL-17 were measured with immunoturbidimetry and ELISA respectively in 80 cases of type 2 diabetic patients with macrovascular complications,80 cases of the absence of any major vascular complications in patients with type 2 diabetes and 80 healthy subjects as the control. Results The serum hs-CRP and IL-17 levels of senium type 2 diabetic Patients with macrovascular complications were significantly higher than those of patients without macrovascular complication and healthy control group(t=19.18,23.14,all P 0.05); In patients of type 2 diabetic Patients with macrovascular complications,hs-CRP was positively correlated with serum IL-17(r=0.712,P<0.05). Conclusion Hs-CRP and IL-17might be involved in the process of inflammatory response to diabetic macroangiopathy, and may have important role in the pathogenesis of senium type 2 diabetic patients with macrovascular complications. Detemination of hs-CRP and IL-17 levels in type 2 diabetic patients may be useful for early detecting diabetic macrovascular complications and serve as the index in monitoring the state of diabetic macrovascular complications. Key words: Diabetes mellitus, type 2; Diabetic Angiopathies; Interleukin-17; C-Reactive Protein; Aged