Research of the Relationship between Interleukin-18 and Type 2 Diabetic Macrovascular Complication

Objective:To study the relationship between serum Interleukin-18 and type 2 diabetic macrovascular complication (MVC).Methods:68 case of type 2 diabetes were divided into macrovascular complications group (48) and non macrovascular complicationsgroup (20) ,and 20 healthy subjects were regarded as the normal controls(NC). Interleukin-18 levels were measured using ABC-ELISA,and the factors related to diabetic macrovascular complications were analyzed by multiple stepwise logstic regressive analysis.Results:Serum Interleukin-18 level was significantly higher in type 2 diabetes group than that in the control(46.03±13.91) pg/ml vs(25.49±9.69) pg/ml,P0.01).Serum Interleukin-18 level was 50.15±12.36 pg/ml in diabetic macrovascular complications group, which was significantly higher than that in the non-diabetic macrovascular complications(Non-MVC)group(36.14±12.58 pg/ml) and in the normal controls(25.49±9.69 pg/ml)(F=32.975,P0.01).To define the independent association between the risk factors and diabetic macrovascular complications, the multiple stepwise logstic regressive analysis was used. Serum Interleukin-18 ,age, course and TG was related independently and significantly with macrovascular complications.Conclusion:The study suggested that Interleukin-18 might be an important independent risk factor for diabetic macrovascular complications.