Effects of ACEI on cell apoptosis in renal hypertension rats with focal cerebral ischemia-reperfusion

Objective To study the effects of ACEI(enalapril)on apoptosis of cell in renal hypertension rats with focal cerebral ischemia-reperfusion.Methods Renal hypertension rats were divided randomly into Enalapril group(A)and hypertension ischemic reperfusion group(B).Normaltension group were dividing into sham-operated group(C)and normaltension ischemia and reperfusion group(D).The focal cerebral ischemia model was estab- lished in Wistar rats by using the method of thread inserting left middle cerebral artery occlusion(MCAO)for 2h, then reperfusion 22h.The expression of bcl-2 and bax were measured by immunohistochemistry.The apoptosis of cell was analyzed by TDT-mediated dUTP-bioten nick end labeling(TUNEL).Results Compared with B and D, the neurological evaluation of A was lower(P0.05).As compared with B,the neurological evaluation of D was lower(P0.05).Compared with B and D,the expreesion of bcl-2 were higher and the expression of bax and the number of apoptosis were lower in A(P0.05).Compared with B,the expression of bcl-2 was higher and the ex- pression of bax and the number of apoptosiscells were fewer in D(P0.05).Conclusion ACEI(Enalapril)can improve the neurological function and upregulate the expression of bcl-2,inhibit the expression of bax,and decrease the number of apoptosis in rats with focal cerebral ischemia-reperfusion.