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Clinical Relevance of Combined Detection of HPV-DNA and TCT for Early Cervical Lesions

Ling Wang

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Abstract

Objective To explore the clinical relevance of combined detection of thin prep liquid-based cytology(TCT) and human papillomavirus(HPV) DNA in screening for early cervical lesions.Methods The thin prep liquid-based cytology detection was carried out in 375 cases of HPV-DNA positive patients.The results of TCT and HPV-DNA were analyzed by TBS reporting method.Results The number of benign reactive changes was 273(72.8%) in TCT examiner of 375 cases of HPV-DNA positive patients.The number of ASC positive was 84 cases(22.4%),LSIL positive was 6 cases(1.6%) and HSIL-positive was 12 cases(3.2%).The infection rates of sub-type of HPV high-risk were 69.23%,92.86%,100% and 100% respectively.Conclusion The combined detection of TCT with HPV-DNA could improve the diagnosis rate for early cervical lesions.

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What this paper is about

Objective To explore the clinical relevance of combined detection of thin prep liquid-based cytology(TCT) and human papillomavirus(HPV) DNA in screening for early cervical lesions.Methods The thin prep liquid-based cytology detection was carried out in 375 cases of HPV-DNA positive patients.The results of TCT and HPV-DNA were analyzed by TBS reporting method.Results The number of benign reactive changes was 273(72.8%) in TCT examiner of 375 cases of HPV-DNA positive patients.The number of ASC positive was 84 cases(22.4%),LSIL positive was 6 cases(1.6%) and HSIL-positive was 12 cases(3.2%).The infection rates of sub-type of HPV high-risk were 69.23%,92.86%,100% and 100% respectively.Conclusion The combined detection of TCT with HPV-DNA could improve the diagnosis rate for early cervical lesions.

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Available abstract

Objective To explore the clinical relevance of combined detection of thin prep liquid-based cytology(TCT) and human papillomavirus(HPV) DNA in screening for early cervical lesions.Methods The thin prep liquid-based cytology detection was carried out in 375 cases of HPV-DNA positive patients.The results of TCT and HPV-DNA were analyzed by TBS reporting method.Results The number of benign reactive changes was 273(72.8%) in TCT examiner of 375 cases of HPV-DNA positive patients.The number of ASC positive was 84 cases(22.4%),LSIL positive was 6 cases(1.6%) and HSIL-positive was 12 cases(3.2%).The infection rates of sub-type of HPV high-risk were 69.23%,92.86%,100% and 100% respectively.Conclusion The combined detection of TCT with HPV-DNA could improve the diagnosis rate for early cervical lesions.

Key concepts: Medicine, Clinical significance, Human papillomavirus, Liquid-based cytology, Cervical cancer, Cytology, Internal medicine, HPV infection

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