Value of TCT and HPV in the Diagnosis of Cervical Lesions

Objective:To Discuss the value of thinprep liquid-based cytology test(TCT) and HPV DNA test in the diagnosis of cervical disease.Methods:A total of 1391 cases in Cervical outpatient were examined for TCT in the Third People's Hospital of Hefei,abnormal TCT were examined for HPV DNA test and for colposcope biopsy histology,And with pathological results for gold standard.In 218 cases of TCT positive patients,compare two kinds of detection methods sensitivity in TCT and HPV DNA test.Results:Among the 218 cases with abnormal TCT,The detection sensitivity by HPV DNA test was 87.25%,The detection sensitivity by TCT was 71.56%.Compared the difference was statistically significant.(P0.05).With TCT and pathological level increases,HPV positive rate is on the rise.Conclusion:For cervical cancer and precancerous lesion screening and early diagnosis,TCT has certain false positive and false negative rate.TCT Combined HPV DNA test can improve cervical abnormal cell detection rate and reduce false negative.