Effect of atorvastatin combined with enapril on isolated systolic hypertension in senile patients

Objectives To observe the effects of atorvastatin combined with enapril on pulse pressure (PP) in senile patients with isolated systolic hypertension(ISH). Methods Seventy-eight normocholesterolemic senile patients were divided into 2 groups. Enapril 10 mg/d was taken by 38 subjects in control group, 40 subjects in treatment group were administered with enapril 10 mg/d and atorvastatin 20 mg/d orally. Blood pressure was followed-up and recorded every two weeks for 12 week. Results The PP of senile patients with ISH in control group decreased from pretreatment (74.±8) mm Hg to (68±6) mm Hg in week 12 of therapy. The treatment group had a significant PP improvement from pretreatment(75 ± 7)mm Hg to(60 ± 6)mm Hg(P0.01). Conclusions A combined treatment with atorvastatin and enapril is helpful to the PP improvement in senile patients with ISH.