Effect of Combined Treatment of Simvastatin and Amlodipine on Pulse Pressure in Senile Patients with Isolated Systolic Hypertension

Objective To observe the effects of combined treatment of simvastatin and Amlodipine on pulse pressure(PP) in senile patients with isolated systolic hypertension(ISH).Methods 58 old patients with normal level cholesterol were divided into the 2 groups.Amlodipine of 5 mg/d dosage was taken by 28 subjects in control group.30 cases in treatment group were administered orally with Amlodipine of 5 mg/d dose and 10 mg/d simvastatin.Blood pressure was followed up and recorded every two weeks for 12 weeks.Results After treatment the PP decreased from pretreatment(72.1±9.5) mm Hg to(63.8±7.6) mm Hg in control group.Atorvastatin combined with Amlodipine resulted in a significant improvement of PP from pretreatment(71.3±8.2) mm Hg to(58.9±6.1) mm Hg.There was a significant difference between two groups for PP after treatment(P0.01).Conclusion A combination treatment with simvastatin and Amlodipine is helpful to the PP improvement in old patients with ISH.