Effect of combined treatment of atorvastatin and losartan on pulse pressure in senile patients with isolated systolic hypertension

AIM To observe the effects of combined treatment of atorvastatin and losartan on pulse pressure(PP) in senile patients with isolated systolic hypertension(ISH).METHODS Sixty-two normocholesterolemic senile patients were divided into the 2 groups.Losartan of 50 mg·d~(-1) dosage was taken by thirty subjects in control group.Thirty-two in treatment group were administered with losartan of 50 mg·d~(-1) dose and 20 mg·d~(-1) atorvastatin orally.Blood pressure was followed-up and recorded every two weeks for 12 wk.RESULTS The PP of senile patients with ISH in control group decreased from pretreatment(74.67±7.77)mm Hg to(67.37±5.53)mm Hg in wk 12 of therapy.The treatment group was resulted in a significant PP improvement from pretreatment(75.06±6.96)mm Hg to(59.75±5.92) mm Hg.The difference of PP between 2 groups had obvious statistical significance after treatment(P0.01).CON- CLUSION A combined treatment with atorvastatin and losartan is helpful to the PP improvement of senile patients with ISH.