Clinical research of sequential therapy in duodenobulbar ulcer with Helicobacter pylori

Objective To observe the curative effect of the sequential therapy in the treatment for the duodenobnlbar ulcer with Helicobacter pylori(Hp) infection.Methods 60 activity duodenobulbar ulcer (deer size ≥ 0.3cm in diameter) proved by endosoopy patients with Hp positive who were detected by 14C urea breath test were randomly divided into two groups. Both of these groups were treated with 4-week therapy: Omeprazole(20 mg twice daily) together with either Amoxicillin (0.5g twice daily) and Clarithromyein (1 g twice daily) for the first 10 days (the traditionahriple group) or Amoxicillin(1g twice daily) for the first 5 days, then Clarithromycin (0.5g twice daily) and Metronidazole (0.4g twice daily) at the second five days (the sequential group).Results The ulcer healing rates in the traditional triplegroup and the sequential group were 80% and 90%.The eradication rate of the traditional triple group was77% and that of sequential therapy was 97%.Conclusions Sequential therapy is more effective in ulcer healing and Hp eradication. Key words: Duodenobulbar ulcer;  Helicobacter pylori;  Sequential therapy;  Traditional triple therapy: Eradication rate of Helicobacter pylori