Application of Sequential Therapy in Helicobacter Pylori Infective Gastric Ulcer and the Influence of Smoking on Helicobacter Pylori Eradication

Objective:To observe the curative effect of sequential therapy in treatment of gastric ulcer combined with Helicobacter pylori(Hp) infection and the influence of smoking on Hp eradication.Methods:Eighty-five patients with Hp(+) confirmed by the rapid detection strip of Helicobacter pylori were divided into two groups.The traditional triple-therapy group was treated with Omeprazole 20 mg,Clarithromycin 0.5 g and Amoxicillin 1 g and all were treated twice per day.The sequential therapy group was treated with Omeprazole 20 mg(twice per day),Amoxicillin 1 g(twice per day) at the first 5 days and added with Clarithromycin 500 mg(twice per day) and Metronidazole 400 mg(twice per day) at the last 5 days.The course of treatment continued for 10 days to compare the curative effect and observe the influence of the smokers on Hp eradication in the two groups.Results:The eradication rate in the traditional triple-therapy group was 81.0% and that in the sequential therapy group was 90.7%.There was statistical significance comparing between the two groups.The eradication rate of the smokers and the smoking quitters during the treatment was 50.00% and 89.47% respectively among 646 smokers.Conclusion:Sequential therapy is more effective in Hp eradication especially in that of smoking quitters.Smoking may affect the eradication rate of Helicobacter pylori.