Clinical study on single Shengdaihuang powder for gastrointestinal failure in children with critically ill

Objective To explore the curative effects of single Shengdaihuang powder for gastrointestinal failure in children with critically ill. Methods Seventy-one cases of gastrointestinal failure were randomly divided into the treatment group and control group. Thirty-six patients in treatment group received Shengdaihuang powder, and thirty-five cases in control group were cured with Smecta and Cimetidine. Before and after treatment, the cytokines IL-6, IL-8, and TNF in all patients were measured. Results The effect rate in treatment group was 91. 6%, significantly higher than that in control group(48. 5%)(x2=16. 96,P0. 005);the mortality rate in treatment group was significantly lower than that in control group (x2 = 4. 39,P0. 05). After treatment the cytokines IL-6,IL-8 and TNF in treatment group were significantly decreased (P0. 001 ; 0. 01; 0. 01, respectively); and each factor above in control group was decreased non-significantly (P0. 05). Conclusion Shengdaihuang powder could lower inflammatory mediators, and it is obviously effective for gastrointestinal failure in children.