Effect of early intestinal barrier function protection on severe acute pancreatitis

Objective To investigate the importance of early intestinal barrier function protection in the treatment of severe acute pancreatitis.Methods 60 cases of patients with severe acute pancreatitis were randomly divided into treatment group and control group,each of 30 cases.The control group were given conventional treatment,and the treatment group were added with early intestinal barrier function protection based on the control group.Compared the gastrointestinal dysfunction score,APACHE Ⅱscore,CRP,TNF-α,plasma endotoxin level,L/M and the conditions of prognosis of 2 groups.Results 3、5 and 7 days after treatment,the APACHE Ⅱ score and gastrointestinal function scores of the treatment group were significantly decreased Compared with before treatment and the control group;5 and 7 days after treatment,the APACHE Ⅱ score and gastrointestinal function scores of the control group were significantly decreased Compared with before treatment,and the differences were statistically significant(P0.01 and P0.05).7 days after treatment,the L/M and endotoxin of the treatment group were lower than before treatment;3、5 and 7 days after treatment,the L/M of the control group was higher than before treatment;3、5 and 7 days after treatment,the L/M of the treatment group was lower than that of the control group;7 days after treatment,the endotoxin of the treatment group was lower than that of the control group,and the differences were statistically significant(P0.01 and P0.05).The level of CRP、TNFα of 2 groups increased firstly and then decreased later.5 and 7 days after treatment,the CRP level of the treatment group was lower than before treatment;3、5 and 7 days after treatment,the TNFα of the treatment group was lower than before treatment;3、5 and 7 days after treatment,the CRP and TNF-α level of the treatment group were lower than that of the control group,and the differences were statistically significant(P0.01 and P0.05).The poor prognosis incidence of the treatment group was significantly lower than that of the control group,and the difference was statistically significant(P0.05).Conclusion Early intestinal barrier function protection can effectively improve patients' gastrointestinal function and reduce intestinal barrier permeability and inflammatory responses.