Short-term efficacy of tirofiban administered before PCI in patients with acute ST elevated myocardial infarction

Objective To evaluate the efficacy of adjunctive use of tirofiban before percutaneous coronary intervention(PCI) in patients with acute ST elevated myocardial infarction(STEMI) through retrospective study.Methods 80 patients with acute STEMI receiving acute PCI and tirofiban were enrolled and divided into group A and group B according to when tirofiban was used.Patients in group A use tirofiban before PCI,while that in group B use tirofiban during or after PCI.The rate of TIMI grade 3 flow in the infarction related artery(IRA),major cardiovas-cular events and bleeding risks were compared between the two groups.Results In group A,the rate of TIMI grade 3 flow in the IRA was statistically higher compared with that of group B(25% vs 6.3%,P=0.040).Heart failure(HF) in 30 days was statistically lower(12.5% vs 33.3%,P=0.035).Bleeding risks showed no statistically significant differ-ence.Conclusion The use of Tirofiban before acute PCI in patients with acute STEMI in early stage might improve myocardial perfusion and decrease ardiovascular events such as HF.