Effects of tirofiban on patients with acute ST-elevation myocardial infarction undergoing PCI

Objective To study the therapeutic effects and safety of tirofiban on acute ST-elevation myocardial infarction(STEMI)patients undergoing PCI.Methods 80 patients with STEMI were randomized to receive tirofiban(n=40)or no(t n=40).TIMI flow,percentage of ECG-ST(sumSTR),Reperfusion arrhythmia,left ventricular ejection fraction(LVEF)and bleeding status were measured during PCI or 7days post-PCI.Results Baseline characteristics of patients between tirofiban and control groups were similar(P0.05).During PCI,TIMI 3 flow was high in tirofiban group compared to control group(38 VS 30,P0.05).SumSTR was high in tirofiban group compared to control group(15 VS 7,P0.05).However,no significant changes were found in bleeding in both two groups for 7 days post-PCI.Conclusion Tirofiban was shown to be a beneficial on TIMI 3 flow and sumSTR.Tirofiban do not increase the incidence of bleeding in patients with STEMI undergoing PCI.