The investigation of tirofiban in patients with acute myocardial infarction after primary percutaneous coronary intervention

Objective To investigate the coronary perfusion and heart function of glycoprotein Ⅱb/Ⅲa receptor blockade tirofiban in patients with ST-segment elevated myocardial infarction(STEMI) after primary percutaneous coronary intervention(PCI).Methods 100 patients with STEMI underwent primary PCI were divided into the tirofiban group(n=50) and the control group(n=50).Thrombolysis in myocardial infarction(TIMI) grades were evaluated,the resolution of elevated ST-segment after PCI and left ventricular ejection fraction(LVEF) were analyzed.Results ①TIMI grade 0～2 was lower in tirofiban group(10 cases vs.29 cases,P 0.05) and grade 3 was higher in the tirofiban group than the control group(40 cases vs.21 cases,P 0.05).②ST-segment resolution rate in the tirofiban group was higher than that in the control group.③LVEF was higher in the tirofiban group than that in the control group [(60±8)% vs.(53±10)%,P 0.05).Conclusions Tirofiban improves coronary perfusion and heart function in patients with STEMI after primary PCI.