Tirofiban in emergency percutaneous coronary intervention of acute ST-elevation myocardial infarction

Objective To discuss the curative effect of tirofiban on myocardial reperfusion used before percutaneous coronary intervention(PCI)in the patients with acute ST-elevation myocardial infarction(STEMI).Methods STEMI patients(n=84) were divided into the tirofiban group(n=61) and control group(n=23) according to whether they had chest pain.The control group was given aspirin and clopidogrel,and the tirofiban group,tirofiban besides routine treatment.The influences of tirofiban on coronary blood flow,ST-segment resolution after PCI for one hour,CK-MB peak value and bleeding were observed.Results The occurrence of TIMI grade 1 flow before PCI,and occurrence of TIMI grade 3 and 2 after PCI in the tirofivan group were superior to those in the control group(all P0.05).The comparisons in CK-MB peak value and ST-segment full resolution rate one hour after PCI between two groups showed statistical differences(all P0.05).The percentage of mild bleeding was 29.51% in the tirofiban group and 8.70% in the control group and the difference was statistically significant(P0.05).Conclusion Tirofiban can improve TIMI flow before and after PCI and is helpful to reperfusion of ischemia myocardial,but increases the risk of mild bleeding.