Research on correlation between serum pepsinogen and Helicobacter pylori Ig G antibody in high humidity environment

Objective To investigate the situation of serum Helicobacter pylori(Hp)IgG antibody and pepsinogen(PG)level change among native population in the high humidity area,and to understand the correlation between PG with Hp infection.Methods Serum level of pepsinogen was measured with time-resorved fluoroimmunoassay,and Helicobacter pylori antibody with immunogold filtration assay in 136 cases of serum samples.Results Serum PGⅠ level in the Hp IgG antibody positive group was(143.7±87.57)μg/L,which was higher than(123.89±72.47)μg/L in the Hp IgG antibody negative group,but without statistically significant difference(P0.05);the serum PGⅡ level in the Hp IgG antibody positive groupwas(19.48±13.88)μg/L,which was significantly higher than(12.55±9.78)μg/L in the Hp IgG antibody negative group,the difference was statistically significant(P0.01);the serum PGⅠ/PGⅡ level in the Hp IgG antibody positive group was 9.09±4.59,which was significantly lower than 11.48±4.76 in the Hp IgG antibody negative group,the difference was statistically significant(P0.05);The difference in test of Hp antibody and PG in serum had no statistically significant difference among native population in the high humidity area(P0.05).Conclusion The serum PGⅡ level in the Hp IgG antibody positive population is higher than that in the Hp IgG antibody negative population,while serum PGⅠ/PGⅡ is significantly decreased,which suggests that the risk of gastric fundus mucosal lesions among residents in high humidity environment is higher and the detection of Hp and gastric fundus mucosa should be paid more attention to.