The diagnosis value of serum pepsinogen,gastrin-17 and IgG anti-Helicobacter pylori antibody in patients with atrophic gastritis

Objective To investigate the relationship between the serum pepsinogen(PG)Ⅰ,PGⅡ,PGⅠ/PGⅡratio,gastrin-17(G-17),IgG anti-Helicobacter pylori(IgG anti-HP) antibody and atrophic gastritis(AG) and their diagnostic values.Methods The levels of serum PGⅠ,PGⅡ,G-17 and IgG anti-HP were detected by emulsion immunoturbidimetry and enzyme-linked immunosorbent assay(ELISA) in 48 patients with AG and 48 healthy subjects as controls.The best cut-off value to screen AG was established according to the receiver operating characteristics(ROC) curve.Results The levels of serum PG I,PG I/PGⅡratio and G-17 in the AG group were significantly lower than those in the control group,while the levels of serum PGⅡ and IgG anti-HP were significantly higher than those in the control group(P0.01).Serum PGI,PGⅡ,PG I/PGⅡratio,G-17 and IgG anti-HP levels in different atrophy regions had statistical significant difference(P0.01).According to the ROC curves,the best cut-off values of PG I,PG I/PGⅡratio,G-17,IgG anti-HP were 46.7ng/L(sensitivity 82.4%,specificity 80.0%,area under curve 0.831±0.084),4.60(sensitivity 94.4%,specificity 85.7%,area under curve 0.942±0.041),7.45 pmol/L(sensitivity 50.0%,specificity 72.2%,area under curve 0.579±0.108) and 78.9 IU(sensitivity 55.6%,specificity 85.7%,area under curve 0.746±0.089).Conclusions The detection of serum PG I,PG I/PGⅡratio,G-17 and IgG anti-HP levels can be useful to screen AG,and the PG I/PGⅡratio may be the best single parameter for the diagnosis of AG.