Effect of Mycobacterium vaccine on patients with condyloma acuminatum and cellular immunity

Objective To study the effect of Mycobacterium vaccine on the patients with condyloma acuminatum(CA)and cellular immunity.Methods Patients of CA were randomly divided into treatment group(M.vaccine and laser group)and control group(laser group).Double-antibody sandwich ELISA(DAS ELISA)was used to study the serum levels of interleukin-10(IL-10)and interferon-gamma(IFN-γ)in CA patients(before and after treatment with or without vaccine).Results After treatment,the levels of IL-10 in the treatment group were significantly decreased while the levels of IFN-γ were significantly increased(P0.05).There was no significant difference in the control group(P0.05).The effect on the treatment group was much better than that on the control group(P0.05).The relapse rates of the treatment group and the control group were 13.8% and 42.9% respectively.And there was significant difference between them(P0.05).Conclusion Vaccae could improve the cellular immune function of patients with CA,and decrease the relapse rate of CA.