Immune effect of acupoint-injection on condyloma acuminatum

Objective:To investigate immune modulatory and curative effect of acupoint-injection with BCG polysaccharide nuclear acid on the patients with condyloma acuminatum. Methods:149 cases of condyloma acuminatum were divided randomly into the trial group(group A),the drug control group (group B),the non-drug treatment control group (group C).After removed the CA by laser,the group A was treated with acupoint-injection of BCG polysaccharide nuclear acid in LI11 and SP6 or in SP9 and LR3;the group B was treated with injection of BCG polysaccharide nuclear acid twice a week;the group C was just removed the CA by laser.In the groups above,the levels of cellular immunity were assayed before therapy and 6 months after therapy.The follow-up survey were made in 3 months,between 3 months and 6 months,and after 6 monthes to observe and record the cases of relapse.Another control group was made up of 40 healthy cases,accepting the same assays as the above.Results: Compared with the healthy cases,the ratio of CD4+ CD4+/CD8+ and NK-cell cytoactivity declined while CD8+ rised in the patients with CA before treatment.It showed difference in statistics (P0.05).After cured with acupoint-injection of BCG polysaccharide nuclear acid,the ratio of CD4+ CD4+/CD8+ and NK-cell cytoactivity rised while CD8+ declined.Compared group A with group B C,It showed significant difference in statistics(P0.05).Between the relapse and recovery of the group A,the difference also had a statistics meaning (P0.05).Conclusion:Acupoint-injection of BCG polysaccharide nuclear acid has a positive adjustment on CD4+ CD4+/CD8+and NK-cell cytoactivity in the patients with CA.Meanwhile,it can obviously reduce the high recurrence rate of CA.Adjustment of cellular immunity is one of the physipathologies to prevent the relapse of CA with the therapy of acupoint-injection.